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Some results from MedLine, searching for HADS, access provided by Community of Science in 1996

Citation: Leung CM, Ho S, Kan CS, Hung CH, Chen CN, Evaluation of the Chinese version of the Hospital Anxiety and Depression Scale. A cross-cultural perspective., Int J Psychosom 40: 1-4, 29-34, , 1993.
Abstract
The authenticity of the Chinese translation of the Hospital Anxiety and Depression Scale (HAD) was tested in a sample of medical students. The Chinese version demonstrated good agreement with the English original. There was a large difference between the mean anxiety and depression subscores. Factor analysis consistently yielded three factors, suggesting the existence of a somatic factor. It is suggested that a common cut-off point for the subscales of the HAD scale is not advisable and a multidimensional model for mood disorders is more appropriate in a cross-cultural context.

Citation: Lam CL, Pan PC, Chan AW, Chan SY, Munro C, Can the Hospital Anxiety and Depression (HAD) Scale be used on Chinese elderly in general practice?, Fam Pract 12: 2, 149-54, Jun, 1995.
Abstract
A study was carried out in a general practice in Hong Kong to find out if the Hospital Anxiety and Depression (HAD) Scale could be used to detect psychological problems in Chinese elderly. The HAD Scale was translated into Cantonese and administered by an interviewer to 298 Chinese aged 60 or above before their doctor consultations. The acceptance rate of the Scale was 96% and each interview took only 5-10 min to complete. All 298 elderly understood and completed the HAD Scale. Validation of the results of the HAD Scale by the Clinical Interview Schedule (CIS) was done on a random sample of 100 elderly. Relative operating characteristic (ROC) analysis showed that the optimal cut-off points of the HAD Scale was a depression score of 6 and an anxiety score of 3. The sensitivity was "80%", specificity was 90%, OMR (overall misclassification rate) was 12%, positive predictive value was 67% and negative predictive value was 95%. Thirty-six per cent of the elderly had scores above these cut-off points. More females than males had high anxiety scores. Nearly half of those with positive HAD scores were not known to have any psychological illness. The HAD Scale has great potential to be used as a screening instrument for psychological illnesses in Cantonese-speaking Chinese elderly all over the world.

Citation: Abiodun OA, A validity study of the Hospital Anxiety and Depression Scale in general hospital units and a community sample in Nigeria., Br J Psychiatry 165: 5, 669-72, Nov, 1994.
Abstract
BACKGROUND. The utility of the Hospital Anxiety and Depression Scale (HADS) as a screening instrument for anxiety and depressive disorders in non-psychiatric units (medical & surgical wards; gynaecology & antenatal clinics of a teaching hospital) and a community sample in Nigeria was investigated. METHOD. A two-stage screening procedure was employed. This involved the use of GHQ-12/GHQ-30 and HADS against the criteria of a standardised (PSE schedule) psychiatric interview, with psychiatric diagnosis assigned in accordance with ICD-9 criteria.

RESULTS. Sensitivity for the anxiety sub-scale ranged from 85.0% in the medical and surgical wards to 92.9% in the ante-natal clinic, while sensitivity for the depression sub-scale ranged from 89.5% in the community sample to 92.1% in the gynaecology clinic. Specificity for the anxiety sub-scale ranged from 86.5% in the gynaecology clinic to 90.6% in the community sample, while specificity for the depression sub-scale ranged from 86.6% in the medical and surgical wards to 91.1% in the ante-natal clinic and community sample. Misclassification rates ranged from 9.9% in the community sample to 13.2% in the medical and surgical wards. Relative Operating Characteristic (ROC) analyses showed the HADS and the GHQ-12 to be quite similar in ability to discriminate between cases (anxiety and depression) and non-cases.

CONCLUSIONS. The HADS is valid for use as a screening instrument in non-psychiatric units and although initially developed for use in hospital settings, it could be usefully employed in community settings of developing countries to screen for mental morbidity.

Citation: el-Rufaie OE, Absood GH, Retesting the validity of the Arabic version of the Hospital Anxiety and Depression (HAD) scale in primary health care., Soc Psychiatry Psychiatr Epidemiol 30: 1, 26-31, Jan, 1995.
Abstract
The Arabic version of the Hospital Anxiety and Depression (HAD) scale was retested and cut-off points determined in a sample of 217 patients attending a primary health care centre in Al Ain, United Arab Emirates (U.A.E.). Subjects were screened using the HAD scale and all patients were then interviewed by a single consultant psychiatrist. The scale scores were assessed against the psychiatrist's clinical evaluations. The study furnished evidence that the Arabic version of the HAD scale is a valid instrument for detecting anxiety and depressive disorders in primary health care settings. Spearman rank correlations of all items of the scale were significantly above zero. The butterflies item of the anxiety subscale had the lowest correlation coefficients. The overall Cronbach alpha measures of internal consistency were 0.7836 and 0.8760 for anxiety and depression, respectively. The cut-off points that produced a balanced combination of sensitivity and specificity appropriate for referral to a psychiatric facility by the general practitioner were 6/7 for anxiety and 3/4 for depression. Almost all other similar studies have determined a single cut-off point for both subscales of the HAD. This study also indicated that the HAD depression subscale is more consistent and more predictive than the HAD anxiety subscale. Moreover some of the problems arising from applying psychiatric research instruments across cultures are highlighted by this study.

Citation: Silverstone PH, Poor efficacy of the Hospital Anxiety and Depression Scale in the diagnosis of major depressive disorder in both medical and psychiatric patients., J Psychosom Res 38: 5, 441-50, Jul, 1994.
Abstract
The Hospital Anxiety and Depression scale (HAD) is a brief questionnaire which was designed to indicate the likely presence of a depressive disorder in medically ill patients. However, more recently it has been used in several research studies to determine the presence of depression in both medical and psychiatric patients. The aim of the present study was to validate the usefulness of the HAD when used in this way. The HAD was compared to DSM-III-R diagnoses of major depressive disorder in 153 medical inpatients and 147 psychiatric out-patients. In both groups the sensitivity of the HAD was between 80 and "100%" using the cut-off point of 8. However, the positive predictive value (PPV) of the HAD was only 17% in medical patients and 29% in psychiatric patients. Changing the cut-off point for depression or using the total HAD score did not significantly improve the PPV. These findings suggest that the HAD does not accurately determine the presence of DSM-III-R major depressive disorder in medical or psychiatric patients, and should not be used as a research instrument for this purpose. Nonetheless, the HAD should still be used for its original purpose, namely as a clinical indicator as to the possibility of a depressive disorder.

Citation: Maher EJ, Mackenzie C, Young T, Marks D, The use of the Hospital Anxiety and Depression Scale (HADS) and the EORTC QLQ-C30 questionnaires to screen for treatable unmet needs in patients attending routinely for radiotherapy., Cancer Treat Rev 22 Suppl A: 123-9, Jan, 1996.

Citation: Javed MA, Psychiatric morbidity among male students., JPMA J Pak Med Assoc 44: 4, 85-6, Apr, 1994.
Abstract
An epidemiological study was conducted to assess the mental health problems of first year male students studying in two educational institutions. Based on the findings of general health questionnaire and hospital anxiety and depression scale, the estimated prevalence of psychological disturbance was found to be 33% for the whole sample. Present findings are discussed in terms of early identification and provision of better health facilities for the students population.

Citation: Paterson AJ, Lamb AB, Clifford TJ, Lamey PJ, Burning mouth syndrome: the relationship between the HAD scale and parafunctional habits., J Oral Pathol Med 24: 7, 289-92, Aug, 1995.
Abstract
This study investigated 84 patients with burning mouth syndrome (BMS), who were asked to complete a hospital anxiety and depression (HAD) scale questionnaire. A control group of 69 patients was also included. All patients were interviewed regarding parafunctional habits and were subjectively examined for signs of occlusal wear of the natural teeth or dentures. The results demonstrated that parafunctional habits were present in 61% of patients with BMS. There was a statistically significantly relationship between parafunctional habits and anxiety as indicated by the HAD scale, but not with depression.

Citation: Clark DA, Steer RA, Use of nonsomatic symptoms to differentiate clinically depressed and nondepressed hospitalized patients with chronic medical illnesses., Psychol Rep 75: 3 Pt 1, 1089-90, Dec, 1994.
Abstract
The differential sensitivity of the Depression subscale scores of the Hospital Anxiety and Depression Scale and the Cognitive-Affective subscale scores of the revised Beck Depression Inventory were compared for 21 chronic medically ill hospitalized patients with DSM-III--R unipolar depressive disorders and 54 hospitalized medically ill patients without a comorbid psychiatric disorder. Both subscales significantly differentiated these two types of patients beyond the .001 level and yielded comparable effect sizes. The Cognitive-Affective subscale detected clinical depression as well as a specialized self-report measure.

Citation: Psychological factors associated with oral lichen planus., J Oral Pathol Med 273-5, Jul, 1995.
Abstract
50 patients with oral lichen planus (LP) were investigated for current anxiety and depression and for related personality factors. Anxiety levels, as measured on the Hospital Anxiety and Depression (HAD) Scale, were elevated in 50% of cases while depression scores, measured on the same scale, were low in all but a few. The sample profile showed a slight tendency towards anxiety, as measured by the Cattell 16 PF Questionnaire, but did not confirm previous reports of high intelligence and intellectual orientation. There were no statistically significant associations between erosive oral LP and either anxiety or depression, as measured on the HAD Scale, or anxiety as measured by the Cattell 16 PF Questionnaire.

Citation: McCartan BE, 24: 6,

Citation: Farooq S, Gahir MS, Okyere E, Sheikh AJ, Oyebode F, Somatization: a transcultural study., J Psychosom Res 39: 7, 883-8, Oct, 1995.
Abstract
The primary aim of this study was to investigate the comparative rates of somatic complaints between Asian and Caucasian patients in a primary care setting and to characterize the factors associated with increased rates of somatization. One hundred and ninety-five individuals aged between 16 and 65 yr were interviewed with the Bradford Somatic Inventory (BSI) and the Hospital Anxiety and Depression Scale (HAD) respectively. The main finding was that the Asian patients reported significantly more somatic and depressive symptoms than the Caucasian patients. Ethnicity was the most important variable determining this result.

Citation: Velikova G, Selby PJ, Snaith PR, Kirby PG, The relationship of cancer pain to anxiety., Psychother Psychosom 63: 3-4, 181-4, , 1995.
Abstract
The interaction between pain and anxiety in the setting of somatic illness is a widely recognised association. More accurate knowledge about the association and also about the means of assessing anxiety in a clinical setting are of use to the clinician. The present study used the Hospital Anxiety and Depression Scale for assessment of anxiety, and the set of linear analogue scales for detecting the presence and severity of anxiety and pain in an oncology clinic, where patients were undergoing active treatment for cancer. The relationship between pain and anxiety was found to be significant, even when the possible mediating effect of the variables of illness severity and age were removed. The need for detecting anxiety in order to plan treatment strategy is emphasised.

Citation: Caplan RP, Stress, anxiety, and depression in hospital consultants, general practitioners, and senior health service managers [see comments], BMJ 309: 6964, 1261-3, Nov 12, 1994.
Abstract
OBJECTIVE--To study stress, anxiety, and depression in a group of senior health service staff.

DESIGN--Postal survey.

SUBJECTS--81 hospital consultants, 322 general practitioners, and 121 senior hospital managers (total 524). MAIN OUTCOME MEASURES--Scores on the general health questionnaire and the hospital anxiety and depression scale.

RESULTS--Sixty five ("80%") consultants, 257 ("80%") general practitioners, and 67 (56%) managers replied. Of all 389 subjects, 183 (47%) scored positively on the general health questionnaire, indicating high levels of stress. From scores on the hospital anxiety and depression scale only 178 (46%) would be regarded as free from anxiety, with 100 (25%) scoring as borderline cases and 111 (29%) likely to be experiencing clinically measurable symptoms. The findings for depression were also of some concern, especially for general practitioners, with 69 (27%) scoring as borderline or likely to be depressed. General practitioners were more likely to be depressed than managers (69 (27%) v 4 (6%) scored > or = 8 on hospital anxiety and depression scale-D; P = 0.004) with no significant difference between general practitioners and consultants. General practitioners were significantly more likely to show suicidal thinking than were consultants (36 (14%) v 3 (5%); P = 0.04) but not managers (9 (13%)). No significant difference could be found between the three groups on any other measure.

CONCLUSIONS--The levels of stress, anxiety, and depression in senior doctors and managers in the NHS seem to be high and perhaps higher than expected.

Citation: Pergami A, Catalan J, Hulme N, Burgess A, Gazzard B, How should a positive HIV result be given? The patients' view., AIDS Care 6: 1, 21-7, , 1994.
Abstract
The study aimed at obtaining information about the experience of how the diagnosis of HIV infection was given. Thirty asymptomatic HIV seropositive subjects completed a self-report questionnaire enquiring about their views of the process of communication of a positive test result. Subjects' current mood was assessed with the Hospital Anxiety and Depression Scale (HAD). Only about one-third of subjects were definitely satisfied with the way they were told the diagnosis. Satisfaction was associated with perceived reassurance and sympathy, and with the quality of the information given. The views of patients, as reported in this study, should be taken into account when training staff in the notification of HIV test results.

Citation: Bottomley A, The development of the Bottomley Cancer Social Support Scale., Eur J Cancer Care (Engl) 4: 3, 127-32, Sep, 1995.
Abstract
At present, no social support scale exists that is cancer-specific. The objective of the study was to develop a cancer-specific scale that not only had validity in reflecting the experiences of cancer patients, but also one that was quick and easy to use in a busy clinical environment. Sixty patients with a primary diagnosis of cancer were selected from oncology wards and out-patient clinics, and they were administered the Bottomley Social Support Scale and the Hospital Anxiety and Depression Scale. The results indicate a valid and reliable social support scale that could be used in conjunction with other measures in a clinical setting. The clinical implications of the measure are that it will allow medical and support staff to assess the levels of social support and implement any appropriate social support interventions.

Citation: von Essen L, Burstrom L, Sjoden PO, Perceptions of caring behaviors and patient anxiety and depression in cancer patient-staff dyads., Scand J Caring Sci 8: 4, 205-12, , 1994.
Abstract
Cancer patient and staff perceptions of the importance of caring behaviors (Caring Assessment Instrument, CARE-Q) and patient levels of anxiety and depression (Hospital Anxiety and Depression Scale, HADS) were determined in 19 matched patient-staff dyads. Both groups perceived comforting and anticipating behaviors to be among the most important ones. Patients considered behaviors focused on staff explaining and facilitating to be more important than did staff, whereas staff rated behaviors concerning accessibility as more important than did patients. Patient and staff perceptions of the importance of comforting behaviors were negatively associated. No significant mean value difference or correlation was found on the HADS anxiety or depression subscales. Members of matched patient-staff dyads did not agree strongly on the importance of caring behaviors and patient levels of anxiety and depression.

Citation: Kurer JR, Watts TL, Weinman J, Gower DB, Psychological mood of regular dental attenders in relation to oral hygiene behaviour and gingival health., J Clin Periodontol 22: 1, 52-5, Jan, 1995.
Abstract
This study examined the relationship between psychological mood, stress and oral hygiene behaviour in a group of 51 regular dental attenders. Subjects brought a saliva sample for cortisol radioimmunoassay, completed the Hospital Anxiety and Depression (HAD) Scale, were assessed for plaque and gingivitis, and were then instructed in toothbrushing. 5 weeks later, 47 subjects were given a full repeat examination. There was a slight reduction in plaque and gingivitis scores, but no change in mood as assessed by HAD Scale and salivary cortisol concentration. Mean anxiety scores were associated with gingivitis level, and mean depression scores with plaque. Neither mood nor cortisol were predictors of subsequent change in plaque or gingivitis.

Citation: Canney PA, Hatton MQ, The prevalence of menopausal symptoms in patients treated for breast cancer., Clin Oncol (R Coll Radiol) 6: 5, 297-9, , 1994.
Abstract
A survey has been performed to discover the prevalence of menopausal symptoms in 108 patients successfully treated for breast cancer. Patients were assessed by them answering a custom designed questionnaire, and the use of the Hospital Anxiety and Depression (HAD) scale and the Greene Climacteric Scale. During the first year after treatment 70% of women suffered such symptoms; overall 60% of women surveyed were affected. Adjuvant hormonal treatment was the largest contributing factor in the development of symptoms. There was a relationship with borderline cases of anxiety, but not with definite cases of anxiety, as measured by the HAD scale. The high proportion of women shown to be affected means that treatment of menopausal symptoms should be incorporated into randomized trials of adjuvant therapy.

Citation: Millar K, Jelicic M, Bonke B, Asbury AJ, Assessment of preoperative anxiety: comparison of measures in patients awaiting surgery for breast cancer., Br J Anaesth 74: 2, 180-3, Feb, 1995.
Abstract
We have compared three measurements of anxiety to determine their equivalence in assessing anxiety before surgery. Forty-four patients awaiting breast cancer surgery completed the state scale of the state-trait anxiety inventory (STAI), the hospital anxiety and depression scale (HAD) and a 100-mm visual analogue scale (VAS). Analysis restricted to correlations between the scales gave the misleading impression that VAS scores were inconsistent with those of the HAD and STAI. However, when scores were considered in relation to normative cut-off values to categorize anxiety levels, the three scales showed good agreement. We conclude that the scales were equivalent in their assessment of anxiety before surgery, but that reference to normative data was important in establishing such equivalence and in determining the patient's state.

Citation: Pattison HM, Robertson CE, The effect of ward design on the well-being of post-operative patients., J Adv Nurs 23: 4, 820-6, Apr, 1996.
Abstract
Changes in the design of hospital wards have usually been determined by architects and members of the nursing and medical professions; the views and preferences of patients have seldom been sought directly. The Hospital Anxiety and Depression scale and the Disturbance Due to Hospital Noise questionnaire were administered to 64 female patients on bay and Nightingale wards together with a questionnaire designed for this study. Perceptions of social and physical factors of ward design were examined, and their relationship to psychological well-being and sleep patterns. The results show that the bay ward seemed to offer a more favourable environment for patients but some of the disadvantages of bay wards are balanced by better staffing levels and better and more modern facilities. Visibility to nurses was lower on the bay ward. The Nightingale ward was perceived as significantly noisier than the bay ward and noise levels were significantly correlated to anxiety scores. Paradoxically the increase in noise levels appeared to improve the perceived level of privacy on the Nightingale ward. Seventy-five per cent of patients were found to prefer the bay ward design, and since neither design appears to have major disadvantages their continued introduction should be encouraged. However, recommendations are made concerning the optimizing of patients' well-being within the bay ward setting.

Citation: Pattison HM, Robertson CE, The effect of ward design on the well-being of post-operative patients., J Adv Nurs 23: 4, 820-6, Apr, 1996.
Abstract
Changes in the design of hospital wards have usually been determined by architects and members of the nursing and medical professions; the views and preferences of patients have seldom been sought directly. The Hospital Anxiety and Depression scale and the Disturbance Due to Hospital Noise questionnaire were administered to 64 female patients on bay and Nightingale wards together with a questionnaire designed for this study. Perceptions of social and physical factors of ward design were examined, and their relationship to psychological well-being and sleep patterns. The results show that the bay ward seemed to offer a more favourable environment for patients but some of the disadvantages of bay wards are balanced by better staffing levels and better and more modern facilities. Visibility to nurses was lower on the bay ward. The Nightingale ward was perceived as significantly noisier than the bay ward and noise levels were significantly correlated to anxiety scores. Paradoxically the increase in noise levels appeared to improve the perceived level of privacy on the Nightingale ward. Seventy-five per cent of patients were found to prefer the bay ward design, and since neither design appears to have major disadvantages their continued introduction should be encouraged. However, recommendations are made concerning the optimizing of patients' well-being within the bay ward setting.

Citation: Jenkins PL, Lester H, Alexander J, Whittaker J, A prospective study of psychosocial morbidity in adult bone marrow transplant recipients., Psychosomatics 35: 4, 361-7, Jul-Aug, 1994.
Abstract
Forty recipients of bone marrow transplantation were recruited prospectively and assessed pretransplant, at 1 month postdischarge, and at 6 months postdischarge between 1989 and 1990. Assessments included a psychiatric interview, a variety of standardized questionnaires (Hospital Anxiety and Depression Scale, Mental Attitude to Cancer Scale, Psychosocial Adjustment to Illness Scale), and a standardized diagnostic interview. The influence of factors such as depression and anxiety upon length of stay, survival, psychosocial adjustment, and negative prognostic attitudes were examined. In contrast to other studies, little influence was found for psychiatric illness on physical outcome variables, but they did affect psychosocial outcome. The implications of these findings are discussed.

Citation: Jadresic D, Riccio M, Hawkins DA, Wilson B, Shanson DC, Thompson C, Long-term impact of HIV diagnosis on mood and substance use--St Stephen's cohort study., Int J STD AIDS 5: 4, 248-52, Jul-Aug, 1994.
Abstract
Twenty HIV positive and 68 HIV negative subjects were assessed by the Hospital Anxiety and Depression Scale and by the Alcohol and Drugs Frequency Schedule immediately prior to notification of their HIV serostatus and 6 months after serodiagnosis. The 2 groups did not differ significantly in levels of anxiety or depression at baseline or follow-up. There were borderline levels of pathological anxiety prior to notification of HIV serostatus in both groups. The drop to normal levels of anxiety which had occurred by follow-up was significant in the HIV positive group. About a third of subjects in both groups were regularly making use of alcohol and/or drugs, both at baseline and follow-up. Mean levels of weekly alcohol intake for both groups ranged from about 20 to 30 units per week. The drugs most commonly used (in any frequency) were nitrates ('poppers') and cannabis.

Citation: Pritchard CW, Depression and smoking in pregnancy in Scotland., J Epidemiol Community Health 48: 4, 377-82, Aug, 1994.
Abstract
OBJECTIVE--The aim was to examine the association between depressive symptoms and smoking in pregnancy and to investigate the part played by social and psychosocial factors. SETTING--A single Glasgow hospital.

DESIGN--Prospective survey by postal questionnaires at 20 and 30 weeks' gestation. PARTICIPANTS--A total of 395 women (69% of the 572 eligible) parity 1 who booked for delivery between November 1988 and February 1990 took part. MEASUREMENTS--Depressive symptoms were measured using the Hospital Anxiety and Depression Scale. Smoking was self reported. The Life Events Inventory and measures of role specific strain and stress in domestic roles were used to assess psychosocial well being. MAIN

RESULTS--Smokers were more likely than non-smokers to experience depressive symptoms at 20 and 30 weeks' gestation and on both occasions. The excess risk remained substantial and significant after adjustment for social and psychosocial factors.

CONCLUSIONS--Smoking is a significant risk factor for depression in pregnancy. The association of smoking with depression and psychosocial difficulty represents a major problem for interventions intended to reduce smoking in pregnancy.

Citation: Johnson G, Burvill PW, Anderson CS, Jamrozik K, Stewart-Wynne EG, Chakera TM, Screening instruments for depression and anxiety following stroke: experience in the Perth community stroke study., Acta Psychiatr Scand 91: 4, 252-7, Apr, 1995.
Abstract
Evaluation of the relative efficacy of three screening instruments for depression and anxiety in a group of stroke patients was undertaken as part of the Perth community stroke study. Data are presented on the sensitivity and specificity of the Hospital Anxiety and Depression Scale (HAPS), the Geriatric Depression Scale and the General Health Questionnaire (GHQ) (28-item version) in screening patients 4 months after stroke for depressive and anxiety disorders diagnosed according to DSM-III criteria. The GHQ-28 and GDS but not the HADS depression, were shown to be satisfactory screening instruments for depression, with the GHQ-28 having an overall superiority. The performance of all 3 scales for screening post-stroke anxiety disorders was less satisfactory. The HADS anxiety had the best level of sensitivity, but the specificity and positive predictive values were low and the misclassification rate high.

Citation: Malasi TH, Mirza IA, el-Islam MF, Validation of the Hospital Anxiety and Depression Scale in Arab patients., Acta Psychiatr Scand 84: 4, 323-6, Oct, 1991.
Abstract
The Hospital Anxiety and Depression Scale (HADS) was administered to psychiatric out-patients with various diagnoses to assess its validity. The study was also designed to find out whether HADS can differentiate between diagnostic groups based on depression and anxiety symptoms. HADS was able to discriminate patients from controls at a sensitivity of 79% and specificity of 87%. HADS was much less sensitive, specific and diagnostically accurate in identifying anxiety and depressive disorders in the experimental group at a cut-off point of 13 and 10 respectively for both conditions. Possible psychological, social and psychiatric reasons for the results are discussed.

Citation: Mumford DB, Tareen IA, Bajwa MA, Bhatti MR, Karim R, The translation and evaluation of an Urdu version of the Hospital Anxiety and Depression Scale., Acta Psychiatr Scand 83: 2, 81-5, Feb, 1991.
Abstract
The translation of the Hospital Anxiety and Depression Scale (HADS) into Urdu was undertaken by the authors in committee. After examining initial drafts by 6 independent translators, an agreed Urdu text was given to 6 back-translators, and subsequently modified further. The evaluation of the new translation was performed in 3 stages: evaluation of linguistic equivalence of items in a bilingual population; evaluation of conceptual equivalence by examining item-subscale correlations: and evaluation of scale equivalence by 2-way classification of high and low scorers. Satisfactory results at each stage suggest that the Urdu version is a reliable and valid translation of the HADS for use in Pakistan.

Citation: Upadhyaya AK, Stanley I, Hospital anxiety depression scale [letter], Br J Gen Pract 43: 373, 349-50, Aug, 1993.

Citation: Carroll BT, Kathol RG, Noyes R Jr, Wald TG, Clamon GH, Screening for depression and anxiety in cancer patients using the Hospital Anxiety and Depression Scale., Gen Hosp Psychiatry 15: 2, 69-74, Mar, 1993.
Abstract
Nine hundred and thirty inpatients and out-patients with cancer were approached to complete the Hospital Anxiety and Depression Scale (HADS). Eight hundred and nine (86.9%) of those approached participated in this screening. Using the suggested cutoff score of 8 for the anxiety and depression subscales, we found that 47.6% of this population would warrant further psychiatric evaluation. Twenty-three percent (23.1%) had scores 11 or greater and would be the most likely to have had anxiety (17.7%) or depressive (9.9%) disorders based on DSM-III-R criteria. Patients with active malignant disease and inpatient status were more likely to have higher depression scores. The HADS was an easily administered tool that identified a large proportion of cancer patients as having high levels of anxiety or depression. However, clinical psychiatric interviews were not performed, so it is not possible to determine what proportion of patients would benefit from treatment.

Citation: Snaith RP, The hospital anxiety and depression scale [letter; comment], Br J Gen Pract 40: 336, 305, Jul, 1990.

Citation: Mumford DB, Hospital anxiety and depression scale [letter; comment], Br J Psychiatry 159: 729, Nov, 1991.

Citation: Thapar AK, Thapar A, Psychological sequelae of miscarriage: a controlled study using the general health questionnaire and the hospital anxiety and depression scale., Br J Gen Pract 42: 356, 94-6, Mar, 1992.
Abstract
This study was carried out to assess whether psychiatric morbidity after a miscarriage is higher than that associated with early pregnancy. A total of 60 consecutive women admitted to a Swansea hospital with a miscarriage were compared with 62 consecutive women who attended an antenatal clinic at the same hospital, using the 28-item general health questionnaire and the hospital anxiety and depression scale. These were completed both at initial contact and six weeks later. Women who had had a miscarriage were found to be significantly more anxious and scored higher on the subscale for severe depression than the pregnant women, both at initial assessment and six weeks later. At the six week assessment more somatic symptoms were also experienced by the group who had had a miscarriage. This study highlights the psychological disturbance associated with miscarriage. The primary health care team and hospital staff need to take this into consideration when organizing follow up for women who have had a miscarriage.

Citation: Dowell AC, Biran LA, Problems in using the hospital anxiety and depression scale for screening patients in general practice [see comments], Br J Gen Pract 40: 330, 27-8, Jan, 1990.
Abstract
A study was made of the feasibility of screening general practice patients for anxiety and depression using the hospital anxiety and depression scale. A group of consecutive patients aged 18 years and over completed the questionnaire at the surgery and an age and sex matched sample were sent questionnaires by post; 94 patients (84%) returned the postal questionnaire. A further group of 170 consecutive patients coming for consultation were recruited. Using a threshold score of eight and over, 51% of patients screened by post were probable 'cases' of psychiatric disorder and using a score of 11 and over, 28% were 'cases'. These proportions were similar for patients screened when attending the surgery. The findings are discussed in the context of well-person screening, and a strategy for follow-up of probable cases is put forward.

Citation: Snaith RP, Availability of the hospital anxiety and depression (HAD) scale [letter; comment], Br J Psychiatry 161: 422, Sep, 1992.

Citation: Lewis G, Wessely S, Comparison of the General Health Questionnaire and the Hospital Anxiety and Depression Scale [see comments], Br J Psychiatry 157: 860-4, Dec, 1990.
Abstract
The specificity and sensitivity of the HAD, 12-item GHQ and CIS were calculated by comparing the scores of dermatological patients on these tests with a criterion measure of disorder. Since psychiatry, along with many other branches of medicine, does not have an error-free criterion, it was assumed that the criterion was an underlying latent construct which was measured by all of the tests and could be derived by factor analysis from the scores on them. No differences were found between the two questionnaires (HAD and GHQ) in their ability to detect cases of minor psychiatric disorder although they were somewhat less reliable than the CIS.

Citation: Nayani S, The evaluation of psychiatric illness in Asian patients by the Hospital Anxiety Depression Scale [see comments], Br J Psychiatry 155: 545-7, Oct, 1989.
Abstract
Twenty Asian psychiatric patients suffering from neurotic illness completed the Urdu version of the HAD Scale. The results were compared with the Clinical Interview Schedule. Somatic symptoms were significantly related to various measures of anxiety but not to those of depression. This finding contradicts the previously held view of linking somatic symptoms with the presentation of depression.

Citation: Hamer D, Sanjeev D, Butterworth E, Barczak P, Using the Hospital Anxiety and Depression Scale to screen for psychiatric disorders in people presenting with deliberate self-harm., Br J Psychiatry 158: 782-4, Jun, 1991.
Abstract
In-patients referred to a deliberate self-harm team were asked to complete the HAD questionnaire and diagnoses were made using the SCID. The total prevalence of psychiatric disorder by DSM-III criteria was 54%. The HAD performed well as a screening instrument; a threshold score of eight gave a sensitivity of 88% and a positive predictive value of "80%"; its use by non-psychiatrists to detect depressive disorder in patients presenting with deliberate self-harm is to be recommended.

Citation: Moorey S, Greer S, Watson M, Gorman C, Rowden L, Tunmore R, Robertson B, Bliss J, The factor structure and factor stability of the hospital anxiety and depression scale in patients with cancer [see comments], Br J Psychiatry 158: 255-9, Feb, 1991.
Abstract
An exploratory factor analysis of the HAD was carried out in 568 cancer patients. Two distinct, but correlated, factors emerged which corresponded to the questionnaire's anxiety and depression subscales. The factor structure proved stable when subsamples of the total sample were investigated. The internal consistency of the two subscales was also high. These results provide support for the use of the separate subscales of the HAD in studies of emotional disturbance in cancer patients.

Citation: Herrmann C, Scholz KH, Kreuzer H, [Psychologic screening of patients of a cardiologic acute care clinic with the German version of the Hospital Anxiety and Depression Scale], Psychother Psychosom Med Psychol 41: 2, 83-92, Feb, 1991.
Abstract
A German version of the HAD-scale which had originally been developed by Zigmond and Snaith for assessing psychological morbidity in medical patients was tested in 136 medical students, 18 psychiatric and 531 cardiologic patients. Its validity, reliability and acceptance were found to be satisfactory, its integration into medical routine did not raise any problems. Among 203 patients with suspected coronary heart disease (137 men, 66 women; mean age 54 +/- 10 years) the sub-group with high (vs. normal) HAD anxiety scores showed a significantly higher number of negative exercise tests (p less than .05) and coronary angiograms (p = .01; n = 60). Hence, the German HAD version seems to be suitable for a psychological screening of cardiologic patients. In patients with suspected coronary heart disease it improves the non-invasive differentiation between organic and functional causes of chest pain.

Citation: Jelicic M, Bonke B, Millar K, Clinical note on the use of denial in patients undergoing surgery for breast cancer., Psychol Rep 72: 3 Pt 1, 952-4, Jun, 1993.
Abstract
44 patients awaiting surgery for breast cancer completed the Hospital Anxiety and Depression Scale. Thirteen patients had anxiety scores within the normal range, and five of them even scored extremely low in anxiety. These five and possibly all 13 patients were probably using denial as a defense against the stress of major surgery.

Citation: Ali B, Saud Anwar M, Mohammad SN, Lobo M, Midhet F, Ali SA, Saud M [corrected to Saud Anwar M], Psychiatric morbidity: prevalence, associated factors and significance [published erratum appears in JPMA J Pak Med Assoc 1994 Apr;44(4):102], JPMA J Pak Med Assoc 43: 4, 69-70, Apr, 1993.
Abstract
A cross-sectional observational systematic study was carried out on ambulatory patients at a tertiary care hospital to determine the probable prevalence, associated factors and significance of psychiatric morbidity by using an Urdu translation of the hospital anxiety and depression (HAD) scale over a period of 6 days in a week. Results showed a prevalence of 38.4% which is slightly higher than what has been generally reported (30%). Two variables, i.e., female sex and being a housewife were significantly related with the outcome. An attempt has been made to identify the probable reasons for this and some suggestions laid down for further work.

Citation: Zakrzewska JM, Feinmann C, A standard way to measure pain and psychological morbidity in dental practice., Br Dent J 169: 10, 337-9, Nov 24, 1990.
Abstract
Dental surgeons are continually faced with patients in pain. In complicated cases, a measure of pain and its psychological consequences are essential. The McGill Pain Questionnaire measures pain using 78 descriptors and is useful not only in diagnosis but in monitoring treatment outcome. The Hospital Anxiety and Depression Scale is a simple way of assessing anxiety and depression in non psychiatric out-patient clinics. These two scales are compared with other measures that can be used.

Citation: Hopwood P, Howell A, Maguire P, Screening for psychiatric morbidity in patients with advanced breast cancer: validation of two self-report questionnaires., Br J Cancer 64: 2, 353-6, Aug, 1991.
Abstract
Eighty-one patients with advanced breast cancer completed the Hospital Anxiety and Depression Scale (HADS) and Rotterdam Symptom Checklist (RSCL) to determine how well these questionnaires identified patients suffering from an anxiety state or depressive illness, compared with an independent interview by a psychiatrist who used the Clinical Interview Schedule. A threshold score was defined for each questionnaire which gave the optimal sensitivity and specificity. Seventy-five per cent of patients were correctly identified as suffering from an affective disorder by both the Rotterdam Symptom Checklist and by the Hospital Anxiety and Depression Scale. Twenty-one per cent of 'normal' patients were misclassified by the Rotterdam Checklist and 26% by the Hospital Anxiety and Depression Scale. When the HADs anxiety and depression subscales were analysed separately, the performance of the anxiety items was superior to that of the depression items. Both questionnaires were found to have good predictive value and could be used in patients with advanced cancer to help screen out those with an affective disorder.

Citation: Silverstone PH, Low self-esteem in eating disordered patients in the absence of depression., Psychol Rep 67: 1, 276-8, Aug, 1990.
Abstract
Both low self-esteem and depression are well recognised as occurring in patients with eating disorders. 43 patients with eating disorders were studied to assess whether this low self-esteem occurred as part of an affective disorder or was independent of this. The patients, 23 with anorexia nervosa and 20 with bulimia nervosa, were assessed for low self-esteem, using the Rosenberg Self-esteem Questionnaire, and for depression, using the Hospital Anxiety and Depression Scale. The patients had low self-esteem, despite only a minority (33%) being depressed. This study demonstrates that low self-esteem occurs in patients with eating disorders in the absence of depression.

Citation: Thompson DR, Meddis R, A prospective evaluation of in-hospital counselling for first time myocardial infarction men., J Psychosom Res 34: 3, 237-48, , 1990.
Abstract
Self-ratings of anxiety and depression were studied over six months in 60 male patients, under 66 yr of age, who were admitted to a coronary care unit with a first time acute myocardial infarction. Patients were randomly assigned to either a treatment group, where they received a simple programme of in-hospital counselling in addition to routine care, or to a control group, where they received routine care only. All patients completed the Hospital Anxiety and Depression scale and a battery of visual analogue scales measuring anxiety on a range of topics related to recovery from a myocardial infarction. Patients who received in-hospital counselling reported statistically significantly less anxiety and depression than those who received routine care alone. This effect was sustained for six months after leaving hospital. It is concluded that a simple programme of in-hospital counselling, provided by a coronary care nurse, is efficacious and should be routinely offered to first myocardial infarction patients in hospital.

Citation: Thompson DR, Meddis R, Wives' responses to counselling early after myocardial infarction., J Psychosom Res 34: 3, 249-58, , 1990.
Abstract
Self-ratings of anxiety and depression were studied over six months in 60 wives of first time myocardial infarction patients. Couples were randomly assigned to either a treatment group, where they received a simple programme of education and psychological support in addition to routine care, or to a control group, where they received routine care only. All wives completed the Hospital Anxiety and Depression scale and a battery of visual analogue scales measuring anxiety on a range of topics related to recovery from a heart attack. Wives in the treatment group reported statistically significantly less anxiety than controls. This effect was sustained for six months after the counselling. It is concluded that a simple programme of in hospital counselling is efficacious and should be routinely offered to the wives of coronary patients.

Citation: Wands K, Merskey H, Hachinski VC, Fisman M, Fox H, Boniferro M, A questionnaire investigation of anxiety and depression in early dementia., J Am Geriatr Soc 38: 5, 535-8, May, 1990.
Abstract
We report findings on a study of anxiety and depression by questionnaire in 50 patients with mild dementia and 134 control subjects using the Hospital Anxiety and Depression Scale. Thirty-eight percent of patients and 9% of controls had a possible or probable diagnosis of an anxiety disorder. Possible or probable depression was found in 28% of the patients and 3% of the controls. These rates for the patients were above those in normal populations. All patients and control subjects were tested with the Extended Scale for Dementia (ESD). Neither group showed a significant relationship between depression and ESD scores. In the control subjects there was a negative correlation (P less than .006) between anxiety and cognitive scores, one that was not found in the patients.

Citation: Lewin B, Robertson IH, Cay EL, Irving JB, Campbell M, Effects of self-help post-myocardial-infarction rehabilitation on psychological adjustment and use of health services., Lancet 339: 8800, 1036-40, Apr 25, 1992.
Abstract
A home-based exercise programme has been found to be as useful as a hospital-based one in improving cardiovascular fitness after an acute myocardial infarction. To find out whether a comprehensive home-based programme would reduce psychological distress, 176 patients with an acute myocardial infarction were randomly allocated to a self-help rehabilitation programme based on a heart manual or to receive standard care plus a placebo package of information and informal counselling. Psychological adjustment, as assessed by the Hospital Anxiety and Depression Scale, was better in the rehabilitation group at 1 year. They also had significantly less contact with their general practitioners during the following year and significantly fewer were readmitted to hospital in the first 6 months. The improvement was greatest among patients who were clinically anxious or depressed at discharge from hospital. The cost-effectiveness of the home-based programme has yet to be compared with that of a hospital-based programme, but the findings of this study indicate that it might be worth offering such a package to all patients with acute myocardial infarction.

Citation: Rosenqvist S, Berglund G, Bolund C, Fornander T, Rutqvist LE, Skoog L, Wilking N, Lack of correlation between anxiety parameters and oestrogen receptor status in early breast cancer., Eur J Cancer 29A: 9, 1325-6, , 1993.
Abstract
Correlation between anxiety parameters and oestrogen receptor levels (ER) were investigated in 89 patients with primary breast cancer. Patients were divided into two groups, ER poor (< 0.05 fmol/microgram DNA) and ER rich (> 0.05 fmol/microgram DNA). No differences were found between anxiety levels, determined by a modified Hospital Anxiety and Depression (HAD) scale, in the two groups. This report does not support the findings from other studies, claiming an association between psychological parameters and oestrogen receptor status, which is believed to be a prognostic predictor.

Citation: Greenough CG, Fraser RD, Comparison of eight psychometric instruments in unselected patients with back pain., Spine 16: 9, 1068-74, Sep, 1991.
Abstract
A comparative evaluation of eight psychometric instruments was made in 274 patients who were currently suffering or previously had suffered from low-back pain. The specificity and sensitivity values for detection of psychological disturbance were calculated and optimum cutoff scores determined for each test. The influence of current pain, social group, compensation, migrant status, and unemployment on the accuracy of each test were evaluated. The Pain Drawing, the Inappropriate Symptoms, the Inappropriate Signs, and the Illness Behavior Questionnaire were found to be least discriminating. The Modified Somatic Perception Questionnaire, the Hospital Anxiety Scale, the Hospital Depression Scale, and the Zung Depression Scale were the most accurate and least affected by the factors examined. The combination of the Modified Somatic Perception Questionnaire and the Zung Depression Scale yielded specificities and sensitivities of 91% and 84% for men and 96% and 85% for women, respectively. This combination is recommended for the assessment of psychological disturbance in patients with low-back pain.

Citation: Barczak P, Kane N, Andrews S, Congdon AM, Clay JC, Betts T, Patterns of psychiatric morbidity in a genito-urinary clinic. A validation of the Hospital Anxiety Depression scale (HAD)., Br J Psychiatry 152: 698-700, May, 1988.
Abstract
The prevalence of psychiatric disorder (by DSM-III criteria) in a population attending a genito-urinary clinic was found to be 31%. The performance of the Hospital Anxiety Depression (HAD) scale as a screening questionnaire for psychiatric disorder was assessed. Case definition by a score of 8 or more on either of the anxiety or depressive subscales produced optimal results, giving sensitivities of 82% and 70%, and specificities of 94% and 68%, for depressive and anxiety disorders respectively.

Citation: Huston GJ, The Hospital Anxiety and Depression Scale [letter], J Rheumatol 14: 3, 644, Jun, 1987.

Citation: Snaith RP, Zigmond AS, The hospital anxiety and depression scale [letter], Br Med J (Clin Res Ed) 292: 6516, 344, Feb 1, 1986.

Citation: el-Rufaie OE, Absood G, Validity study of the Hospital Anxiety and Depression Scale among a group of Saudi patients., Br J Psychiatry 151: 687-8, Nov, 1987.
Abstract
The Arabic version of the HAD scale was validated in a sample of 50 Saudi patients. The scale scores were assessed against the principal author's clinical evaluations. Spearman correlations of all items of the scale, except for one, were statistically significant. The non-significance of one item was probably related to the way it was translated into Arabic. The study furnished evidence that the Arabic version was a reliable instrument for detecting states of anxiety and depression in Saudi patients in a primary health care setting.

Citation: Wilkinson MJ, Barczak P, Psychiatric screening in general practice: comparison of the general health questionnaire and the hospital anxiety depression scale., J R Coll Gen Pract 38: 312, 311-3, Jul, 1988.

Citation: Lamey PJ, Lamb AB, The usefulness of the HAD scale in assessing anxiety and depression in patients with burning mouth syndrome., Oral Surg Oral Med Oral Pathol 67: 4, 390-2, Apr, 1989.
Abstract
A recent index of anxiety and depression (Hospital Anxiety and Depression Scale) was applied to 74 patients with burning mouth syndrome. The scale pointed to anxiety, more than depression, being a feature of burning mouth syndrome. The validity and clinical application of this scale to assess anxiety and depression in such patients are discussed.

Citation: Aylard PR, Gooding JH, McKenna PJ, Snaith RP, A validation study of three anxiety and depression self-assessment scales., J Psychosom Res 31: 2, 261-8, , 1987.
Abstract
All measuring instruments require further validation both in the setting for which they were designed and in other fields. The Hospital Anxiety and Depression Scale was designed for detection and assessment of those mood disorders in the setting of hospital medical and surgical clinics. Reasons are given for supposing it has advantages over other similar scales. The present study undertakes a further validation of the scale in a general hospital setting. The opportunity is taken to assess the usefulness, in this setting of the Irritability Depression and Anxiety Scale and also of two subscales of the General Health Questionnaire, the one relating to the concept of depression and the other to the concept of anxiety. Score ranges of the latter two subscales are suggested and will require replication for confirmation of their usefulness.

Citation: Snaith RP, Taylor CM, Rating scales for depression and anxiety: a current perspective., Br J Clin Pharmacol 19 Suppl 1: 17S-20S, , 1985.
Abstract
Research now requires instruments capable of a better distinction between depressive and anxiety disorders. The study is concerned with two relatively recent clinician-rated scales, the Montgomery-Asberg Depression Rating Scale and the Clinical Anxiety Scale together with two recent self-assessment scales, the Irritability-Depression-Anxiety Scale and the Hospital Anxiety and Depression Scale. The concurrent validity of these scales as measures of the separate concepts of anxiety and depression is examined.

Citation: Thompson DR, A randomized controlled trial of in-hospital nursing support for first time myocardial infarction patients and their partners: effects on anxiety and depression., J Adv Nurs 14: 4, 291-7, Apr, 1989.
Abstract
This study monitored and compared levels of anxiety and depression reported by first myocardial infarction (MI) male patients and their partners, throughout the patients' hospital stay. An independent variable of a programme of supportive-educative counselling provided by a coronary care nurse was introduced to determine whether it significantly affected reactions. Sixty couples were randomly assigned to one of two groups: (a) the treatment group (in which they received the systematic programme of nursing support in addition to routine care), or (b) the control group (in which they received routine care but no other intervention). Anxiety and depression were measured by the Hospital Anxiety and Depression (HAD) scale at 24 hours and 5 days after the patient's admission to hospital. At 5 days there were statistically significant differences between both groups with respect to the HAD scale mean scores. These findings strongly suggest that a simple programme of in-hospital couple counselling, provided by a coronary care nurse, statistically significantly reduces anxiety and depression in first MI male patients and anxiety in their partners.

Citation: Identifying anxiety and depressive disorders among primary care patients: a pilot study., Acta Psychiatr Scand 280-2, Mar, 1988.
Abstract
One stage case-identification method, using the Arabic Version of the Hospital Anxiety and Depression Scale (HAD) was applied in a pilot study for estimating the prevalence of depressive and anxiety disorders among a group of Saudi primary care attenders. The validity of the Arabic Version of the HAD scale was previously tested and found valid with high sensitivity and specificity. The total prevalence rate of depression was 17% and that of anxiety was 16%. Seven percent of the sample suffered both depression and anxiety i.e. the total percentage of patients with depression, anxiety or both was 26%. Higher morbidity of depression was recorded among females and a higher morbidity of anxiety among male patients.

Citation: el-Rufaie OE, Albar AA, Al-Dabal BK, 77: 3,

Citation: The Scottish First Episode Schizophrenia Study. III. Cognitive performance. The Scottish Schizophrenia Research Group., Br J Psychiatry 150: 338-40, Mar, 1987.
Abstract
Cognitive performance in 46 first episode schizophrenics was assessed within 1 week of admission to hospital by Progressive Matrices, Mill Hill Vocabulary Scale, Block Design and Similarities subtests of the Wechsler Adult Intelligence Scale, and Digit Copying Test. Patients' intellectual performance was at a dull normal level, just within one standard deviation from the mean. There was an association between the presence of anxiety and depression and lower scores on psychological tests. Patients assessed by the Present State Examination as belonging to the 'uncertain psychosis' category performed more poorly.

Citation: Hicks JA, Jenkins JG, The measurement of preoperative anxiety., J R Soc Med 81: 9, 517-9, Sep, 1988.
Abstract
Preoperative anxiety was assessed using the hospital anxiety and depression (HAD) scale, multiple affect adjective check list (MAACL) and linear analogue anxiety scale (LAAS) in 100 consecutive day case patients undergoing termination of pregnancy. The HAD scale, a recently introduced self assessment scale comprising 7 multiple choice questions, was readily accepted and easily understood by patients. There was a high degree of correlation between the HAD scale and both the MAACL (correlation coefficient 0.74) and the LAAS (correlation coefficient 0.67). There was only a moderate degree of correlation between the HAD scale and the anaesthetist's assessment of anxiety (correlation coefficient 0.46). The HAD scale is a useful method of subjective measurement of preoperative anxiety.

Citation: Hashimoto F, Kellner R, Kapsner CO, Upper respiratory tract infections increase self-rated hostility and distress., Int J Psychiatry Med 17: 1, 41-7, , 1987.
Abstract
The authors administered a personality inventory, the Eysenck Personality Inventory and a distress scale, the Symptom Questionnaire, to all patients in a walk-in clinic of a general hospital during an influenza epidemic. Hostility, depression, anxiety and somatic symptoms were significantly higher in patients with upper respiratory tract infections (p less than .005); the majority scored in the range of psychiatric patients, regardless of whether patients had clinically classical influenza or merely symptoms and signs of another respiratory tract infection. There were no differences in the personality traits of extraversion or neuroticism between any of the groups, suggesting that hostility and distress were consequences of the viral infections and were largely unaffected by preexisting personality traits.

Citation: Cundall DB, Children and mothers at clinics: who is disturbed?, Arch Dis Child 62: 8, 820-4, Aug, 1987.
Abstract
One hundred and eighty one white children aged 6 to 11 years who were attending medical out-patient clinics with their mothers were studied to assess the prevalence of psychological disturbance in the children, and anxiety and depression in the mothers. Teachers were also asked to assess the children independently using the Rutter scales. Mothers assessed 70 (39%) of the children as being disturbed, 20 of whom were also assessed as being disturbed by their teachers. A further 15 children were assessed as being disturbed by their teachers but not by their mothers. Thirty five (19%) of the mothers assessed themselves as anxious and two as depressed using the hospital anxiety and depression scale. Anxious and depressed mothers were significantly more likely to assess their child as being disturbed. In contrast, the teachers' assessments of the children were not affected by the mental state of the mothers. These findings confirm that mothers' perceptions of their children are modified by their own moods.

Citation: Robertson DA, Ray J, Diamond I, Edwards JG, Personality profile and affective state of patients with inflammatory bowel disease., Gut 30: 5, 623-6, May, 1989.
Abstract
The Eysenck Personality Inventory and Hospital Anxiety and Depression scale were administered to 80 patients undergoing medical treatment for long standing inflammatory bowel disease: 22 patients were studied before the diagnosis was established and 40 patients with diabetes mellitus served as controls. High neuroticism and introversion scores were more prevalent in the patients with inflammatory bowel disease than controls (p less than 0.05) and these characteristics were as prominent in patients before diagnosis as in established cases. Introversion scores increased with the duration of disease (r = 0.51). Depression was uncommon, occurring only in patients with active chronic disease. Patients believed there was a close link between personality, stress and disease activity. Fifty six of the patients recognised factors that initiated the disease and in 42 this was thought to be a stressful life event or a 'nervous personality'.

Citation: Marsh DT, Stile SA, Stoughton NL, Trout-Landen BL, Psychopathology of opiate addiction: comparative data from the MMPI and MCMI., Am J Drug Alcohol Abuse 14: 1, 17-27, , 1988.
Abstract
The MMPI and MCMI were administered to 163 former opiate addicts who were being maintained in a methadone program affiliated with an urban hospital. Highest group mean MMPI scores were found for Psychopathic Deviate, Depression, Hypomania, and Hysteria. For the MCMI, highest group mean clinical syndrome scores were found for Drug Abuse, Alcohol Abuse, Anxiety, and Dysthymia; highest personality disorder scores were found for Antisocial, Narcissistic, Histrionic, and Paranoid. The MCMI Drug Abuse Scale identified only 49% of subjects as having a recurrent or recent history of drug abuse. Frequency and factor analyses documented the heterogeneity of the population with respect to clinical syndromes, as well as the prevalence of personality disorders (86% had elevations on MCMI Personality Scales). Factor and correlational analyses did not provide strong evidence of similar factor structure or convergent validity of the MMPI and MCMI with this population.

Citation: Ryde-Brandt B, Mothers of primary school children with Down's syndrome. How do they experience their situation?, Acta Psychiatr Scand 78: 1, 102-8, Jul, 1988.
Abstract
The occurrence of anxiety or depression, experience of social support and feelings about the family situation were evaluated in 13 mothers of children of primary school age with Down's syndrome (DS). The results were compared with those obtained in a group of 13 females engaged in taking care of these children and assisting their families. Questionnaires were used to assess feelings of depression or anxiety (Hospital Anxiety and Depression Scale), to evaluate social support (Interview Schedule for Social Interaction) and the family situation (Family Adaptability and Cohesion Evaluation Scale). A semi-structured interview with the mothers was also conducted. The results indicated that negative feelings at the birth of a child with DS had almost invariably changed in a positive direction. Experience of depression or anxiety was uncommon. Social and emotional contacts were quantitatively normal, although more empathy was often desired. The families were relatively often described as enmeshed and controlled, but the experience of the family situation was generally positive.

Citation: Smith J, Carr V, Morris H, Gilliland J, The dexamethasone suppression test in relation to symptomatology: preliminary findings controlling for serum dexamethasone concentrations., Psychiatry Res 25: 2, 123-33, Aug, 1988.
Abstract
A diagnostically heterogeneous sample of psychiatric inpatients (n = 52) was administered the 1 mg dexamethasone suppression test (DST) shortly after hospital admission. Each was also assessed using the Hamilton Rating Scale for Depression (HRSD) and selected items of the Present State Examination (PSE) representing psychomotor retardation and anxiety. A potent determinant of postdexamethasone serum cortisol concentrations was found to be the level of serum dexamethasone concentration achieved following the oral dose. No relationship was found between postdexamethasone cortisol concentration and the scores on either the HRSD or an anxiety scale derived from selected PSE items. However, symptoms of psychomotor retardation were significantly related to postdexamethasone serum cortisol concentration, particularly when the serum dexamethasone concentrations were taken into account. It may be that DST nonsuppression in psychiatric patients is in part a reflection of the presence of psychomotor retardation, a phenomenon that cuts across diagnostic categories.

Citation: Malt U, The long-term psychiatric consequences of accidental injury. A longitudinal study of 107 adults., Br J Psychiatry 153: 810-8, Dec, 1988.
Abstract
One hundred and seven accidentally injured adults were studied while in hospital and assessed prospectively twice more in a mean period of 28 months. The patients were studied by means of taped clinical interviews, including the Comprehensive Psychopathological Rating Scale (which includes the Montgomery-Asberg Depression Rating Scale), and several self-report measures of distress (Schedule of Recent Life Events, General Health Questionnaire, Impact of Event Scale and State Anxiety Inventory) at the three assessments. The total incidence of psychiatric disorders considered to be caused by the accident during the follow-up period was 22.4%. The incidence of non-organic psychiatric disorders caused by the accident was 16.8% at the first follow-up and 9.3% at the final follow-up. Depressive disorders of different severity were most often seen. Only one patient suffered from a post-traumatic stress disorder during the follow-up, and none at the final follow-up (DSM-III). Organic mental disorders were diagnosed in 9.3% of the patients. In 5.6% of the patients this was the only disorder.

Citation: Chandarana PC, Eals M, Steingart AB, Bellamy N, Allen S, The detection of psychiatric morbidity and associated factors in patients with rheumatoid arthritis., Can J Psychiatry 32: 5, 356-61, Jun, 1987.
Abstract
Eighty-six patients with a confirmed diagnosis of rheumatoid arthritis were surveyed to assess the extent of psychiatric morbidity as indicated by two screening questionnaires, the General Health Questionnaire and the Hospital Anxiety and Depression Scale. In addition to an investigation of the concordance of the screening questionnaires, a description of demographic characteristics and measures of disability were taken. Disability due to arthritis was indicated by measures of years of chronicity, pain, duration of morning stiffness, functional level, active treatment involvement, and presence of coexisting medical problems. The relationship of physical symptoms to level of psychiatric distress was investigated. Psychiatric cases were identified using recommended cut off scores on results of the screening questionnaires. GHQ cut off scores of 6/7 identified as "cases" 31.8% of the sample. HADS subscale cut off scores of 8/9 identified 21.4% of subjects with "anxiety" and 19.0% with "depression" scores in the morbid range. Nineteen percent of patients were found to have scores on both tests concurrently in the pathological range.

Citation: Overall JE, Rhoades HM, Moreschi E, The Nurses Evaluation Rating Scale (NERS)., J Clin Psychol 42: 3, 454-66, May, 1986.
Abstract
The Nurses Evaluation Rating Scale (NERS) consists of 16 items designed to capture salient dimensions of psychopathology and nursing care requirements for psychiatric patients. Reliability and validity of the NERS were evaluated by using a total of 3,052 sets of ratings accomplished by 19 staff nurses on a total of 235 adult psychiatric inpatients. All items of the NERS were utilized in describing psychopathology in this sample of patients, although no patient was positive on all items. Factor analysis revealed four distinct clusters of items, which represented higher-order constructs of thinking disturbance, depression, anxiety, and psychomotor retardation. Test-retest reliability was found to be comparable to the reliability of most other clinical assessments of psychopathology. Scoring for the four factors was defined, and analysis of change during first 10 days of hospital stay revealed statistically significant improvement. The NERS appears to be a promising instrument for longitudinal, daily evaluations of inpatient psychopathology as seen in the routine clinical practice of psychiatric nurses.

Citation: Berrios GE, Ryley JP, Garvey TP, Moffat DA, Psychiatric morbidity in subjects with inner ear disease., Clin Otolaryngol 13: 4, 259-66, Aug, 1988.
Abstract
A prospective assessment of psychiatric morbidity in a sample of 207 patients with inner ear disorders, attending an ENT clinic, was carried out. As a group, they were found to have higher psychiatric morbidity on the general health questionnaire (GHQ) than either normal samples or samples affected by other forms of physical disease. Within the sample tinnitus patients scored the highest, and presbyacusis patients the lowest. High GHQ scores predicted an exaggerated self-rating of symptom severity in a visual analogue scale. Past psychiatric history did not play a role in the development of psychiatric morbidity. Elderly subjects complained more often of fear of collapsing in the street but this was not related, as has been suggested, to the subsequent development of agoraphobic symptoms. Factor analysis of GHQ items for the 'cases' yielded 'depression', 'anxiety' and 'personality' factors. No correlation was found between these factors and the rest of the clinical variables. It is concluded that tinnitus shows the clearest association with psychiatric morbidity and hence merits detailed psychological analysis. Such a study has been started at Addenbrooke's Hospital.

Citation: Neuling SJ, Winefield HR, Social support and recovery after surgery for breast cancer: frequency and correlates of supportive behaviours by family, friends and surgeon., Soc Sci Med 27: 4, 385-92, , 1988.
Abstract
In a longitudinal study of recovery after surgery for breast cancer, subjects reported the frequency of, and their satisfaction with, various supportive behaviours on the part of family members, close friends and medical professionals. The reliability of the Multi-Dimensional Support Scale (MDSS) devised for this purpose is described. Measures of psychological, social and physical adjustment approached normality by 3 months post-operation. Frequency of support from all sources decreased as time from surgery passed, whilst satisfaction with support varied with the type of support given and the source from which it was received. Quite different patterns emerged in support needs from professional and non-professional sources, with empathic support being required from all sources, whilst informational support was desired from surgeons, rather than from family and friends. Further, subjects were more discriminating in the amounts of support required from family and friends, such that it was more likely for these sources to give unwanted support than it was for professional sources, from whom many subjects reported inadequate support. Satisfaction with social support was matched with measures of adjustment, and it was found that those satisfied with support from family members were significantly less anxious and depressed in hospital than were those who were not satisfied with support from this source. However, at 1 month post-operation, anxiety and depression levels were significantly related to satisfaction with support from surgeons; and at 3 months post-operation, anxiety and depression measures were significantly related to satisfaction with support from both family members and surgeons.(ABSTRACT TRUNCATED AT 250 WORDS)

Citation: Buckelew SP, DeGood DE, Schwartz DP, Kerler RM, Cognitive and somatic item response pattern of pain patients, psychiatric patients, and hospital employees., J Clin Psychol 42: 6, 852-60, Nov, 1986.
Abstract
Standard psychological tests generally provide a single global score that reflects multidimensional constructs, such as depression and anxiety. This single score, however, integrates a range of item contents, including cognitive/affective, somatic, and behavioral characteristics of these multidimensional constructs. The present study was designed to compare the pattern of item endorsement among chronic pain patients (N = 50), psychiatric inpatients (N = 50), and hospital employees (N = 50) on the SCL-90-R (Derogatis, Rickels, & Rock, 1976). Pain patients reported the highest SCL-90 scale level of Somatization, while the psychiatric inpatients reported the highest level of Anxiety and Depression. Additionally, the within-scale pattern of item responses on the Anxiety and Depression scales differed among groups. Although psychiatric inpatients endorsed equivalent levels of somatic and cognitive items, the pain patients' reports of psychological distress were limited primarily to somatic signs of anxiety and depression. Thus, the interpretation of pain patients' psychological profiles and subsequent treatment recommendations may be inappropriate if based on normative data obtained from psychiatric and/or normal populations.

Citation: Miles MS, Emotional symptoms and physical health in bereaved parents., Nurs Res 34: 2, 76-81, Mar-Apr, 1985.
Abstract
The purpose of this study was to compare the emotional symptoms and physical health of parents whose children had died suddenly in an accident, parents whose children had died following a chronic disease, and nonbereaved parents. Data for this retrospective survey were collected by mailed questionnaires: the Hopkins Symptom Checklist (HSCL), Bereavement Health Assessment Scale, Review of Life Experiences Scale, and a personal-situation questionnaire. Subjects were 30 bereaved parents who had experienced the death of a child following a chronic disease; 31 bereaved parents whose children died in an accident; and 81 nonbereaved parents. Findings indicated significant differences between the bereaved groups and the control group on the total scale score of the HSCL and on the subscales measuring Depression, Anxiety, Somatization, Obsession-Compulsion, and Interpersonal Sensitivity. However, there were no differences on these variables between the two bereaved groups. Bereaved parents with higher concurrent life stresses and parents from a lower socioeconomic background were at higher risk for emotional symptomatology. There were no significant differences among the three groups on the number of physician/nurse visits, number of hospital admissions, number of new or recurrent illnesses, or drug usage. Bereaved parents, however, more frequently reported appetite and sleep problems.

Citation: Zigmond AS, Snaith RP, The hospital anxiety and depression scale., Acta Psychiatr Scand 67: 6, 361-70, Jun, 1983.
Abstract
A self-assessment scale has been developed and found to be a reliable instrument for detecting states of depression and anxiety in the setting of an hospital medical out-patient clinic. The anxiety and depressive subscales are also valid measures of severity of the emotional disorder. It is suggested that the introduction of the scales into general hospital practice would facilitate the large task of detection and management of emotional disorder in patients under investigation and treatment in medical and surgical departments.

Citation: Magni G, Messina C, De Leo D, Mosconi A, Carli M, Psychological distress in parents of children with acute lymphatic leukemia., Acta Psychiatr Scand 68: 4, 297-300, Oct, 1983.
Abstract
Psychological distress in parents of children with acute lymphatic leukemia was evaluated by means of the Symptom Distress Checklist. This scale was administered twice: within a few days after the child's admission to hospital and 8 months later. Twenty-five consecutive, unselected subjects were compared with controls matched for age, sex, marital status and social class. At the first evaluation the sample presented higher mean scores than the controls for anxiety (P less than 0.005), depression (P less than 0.005), sleep disturbances (P less than 0.005) and obsessions (P less than 0.05). An 8 months' follow-up confirmed the persistence of anxiety (P less than 0.05), sleep disturbances (P less than 0.05) and above all depression (P less than 0.005).

Citation: Matson JL, Kazdin AE, Senatore V, Psychometric properties of the psychopathology instrument for mentally retarded adults., Appl Res Ment Retard 5: 1, 81-9, , 1984.
Abstract
One hundred and ten adults, from borderline to severe levels of mental retardation, were assessed through the out-patient clinic of a university-affiliated mental health center and a large state psychiatric hospital. These patients were included only after they had demonstrated the ability to respond to questions of similar difficulty to those presented in the Psychopathology Instrument for Mentally Retarded Adults. This measure was designed by the authors based on DSM III criteria, and covered seven types of psychopathology including schizophrenia, depression, psychosexual disorders, adjustment disorder, anxiety, somatoform disorders, and personality problems. In the present study the psychometric properties of the scale were reviewed and/or evaluated including internal consistency of items and test-retest reliability, and factor analysis.

Citation: Moore NC, Medazepam and the driving ability of anxious patients., Psychopharmacology (Berl) 52: 1, 103-6, Mar 23, 1977.
Abstract
A double-blind crossover trial of Medazepam was carried out in 14 anxious hospital patients. The mean self-adjusted dosage was 16.5 mg daily. The active drug was no more effective than placebo in relieving anxiety, which was rated both clinically and by the Middlesex Health Questionnaire (M.H.Q.) (Crown and Crisp, 1970). This may have been because the dose was relatively low for chronically anxious hospital patients. Even this dosage caused significantly higher scores on the M.H.Q. scale for depression. Braking and driving simulator tests were not adversely affected by Medazepam. In real driving conditions those taking the drug made significantly more technical, but not dangerous, errors. Pulse and blood pressure also were not affected.

Citation: Schiller E, Baker J, Return to work after a myocardial infarction: evaluation of planned rehabilitation and of a predictive rating scale., Med J Aust 1: 23, 859-62, Jun 5, 1976.
Abstract
This paper reports the first recorded controlled trial of cardiac rehabilitation after myocardial infarction in men of working age, viewed as a team intervention effort to facilitate the patient's return to normal work. Our results show that this intervention is helpful in returning to jobs which they can handle successfully men who would otherwise be at risk of remaining unemployed. A previously developed rating scale for predicting return to work after myocardial infarction was used and reevaluated. Employment and occupational level at admission to hospital, work history, availability of the previous job, educational level, family and social stability, age at which regular cigarette smoking commenced, and level of anxiety and depression on a personality scale proved highly predictive.

   
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